Severe Interactions. Does Pantoprazole SODIUM Interact with other Medications? Examples of H2 blocker drugs include cimetidine, famotidine, nizatidine and ranitadine. These medications are not usually taken together. Examples of proton pump inhibitors include esomeprazole, pantoprazole, omeprazole, lansoprazole and rabeprazole. Tips. While this can help with the symptoms of heartburn whenever you eat a meal, it can decrease the absorption of your thyroid medication causing it not to work as well. The FDA warns patients on Plavix not to take Nexium or Prilosec -- or nine other drugs, including Prozac and Tagamet. What is not There are several brand names available over the counter. Omeprazole (Prilosec), Nexium, and other proton pump inhibitor drugs can be affected by taking supplements, and can affect your ability to absorb certain vitamins and minerals. Also included on the list of common prescriptions: proton pump inhibitors, such as Nexium and Prilosec. Your doctor may also suggest you take one at bedtime. These drugs, such as Prilosec (omeprazole), Nexium (esomeprazole), Prevacid (lansoprazole), and Protonix (pantoprazole), are used to treat acid reflux. Proton pump inhibitors (PPIs) have been associated with several severe, even life-threatening side effects when used frequently over an extended period of time. The medication is available both over the counter and by prescription. Of course—they are safe—but unless you have Zollinger Ellison Syndrome, there’s probably no reason. So while it does not create a dangerous situation, the cefuroxime would not be as effective and possibly not effective. St. John's wort, for example, should not be taken with these drugs. If a woman were taking an acid-suppressing drug such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec) or pantoprazole (Protonix) and then were tested for bone mineral density, she might be found to have osteopenia (early bone weakness) or osteoporosis. Prilosec is the brand name for omeprazole, a protein pump inhibitor that is used to reduced the amount of acid in the stomach. They can increase blood levels of benzodiazepines by interacting with the same liver enzymes that clear them from the body. The contraindication for taking cefuroxime while on omeprazole is because omeprazole decreases stomach acid which can significantly reduce the amount of cefuroxime in your system. The parameter used to measure the efficacy of combination regimens for GERD thus far--nocturnal acid breakth … It virtually eliminated peptic ulcer disease—or almost. The drugs keep Plavix from working properly. 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