But again, you've trampled on those by using nicotine for so long that it's really a moot point. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. Common side effects … I can't explain much further, simply because I can't remember what happens when I do it. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. It has a pretty clear anxiolytic effect on me. Treatment should only be continued if beneficial effects are seen. And anything else you might like to add. Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). Mine does shortly up to the point I'm about to make as well, so no judgment. How often do you use Memantine for depression? Auditory effects are negligible on Memantine, an enhanced appreciation for music is apparent, but no more than a slight ringing in the ears will be noticed (Memantine has shown efficacy in treatment for tinnitus so who knows what's going on there). The phenyl ring of RTI-111 is substituted at R3 and R4with chlorine groups. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. Some gastro-intestinal disturbances could be possible however, due to D2 agonism, there's not much info on this. Eventually, this study was ceased and smoking should only be considered when modafinil is prescribed, especially among people with psychiatric conditions that have high comorbidity with nicotine dependence. From a 12 week, placebo controlled 2015 chinese study that gave Memantine to 53 Methadone addicts. When I am in Opioid withdrawal, I cannot tolerate any Nicotine at all, as it greatly agitates my opioid withdrawal. Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. Memantine changed my life, therapeutic use fixed my depression, stopped me from compulsively using Ketamine to treat it, and has given me a quality of life I had only dreamed of, and I get to trip on it once in a while too. And if you can get a hold of some, ibudilast is showing great promise for people with addictions due to its unique effect on microglial inflammation. after unsuccessful treatment from medical professionals, i went on my own trying to find some relief. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. It's clean feeling, compared to DXM. The best part of Memantine is that it's available on the clearnet, although you'll have to find sources yourselves. With that being said, I don't think memantine would be an enjoyable experience for everyone. I always use Nicotine with my Opioids, and never just take one or the other. Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. actually that Memantine prevents the Ca2+ signal from spiking and essentially this is the mechanism that prevents drug tolerance from developing What is it with cough suppressants getting us high as shit? Click here to read the full article @ The European respiratory journal Make sure you follow the RULES. By using our Services or clicking I agree, you agree to our use of cookies. the headspace has much less "static" noise, even compared to being sober. As many comparisons to other common compounds as possible would be extremely useful for fleshing out the subjective effects section. So in a way it will only help you out. Page 1 of 3 - Memantine Has Obliterated My Depression and Social Anxiety - posted in Mental Health: Hey all, just wanted to briefly share my experience here. Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). That means the stronger receptor is activated, the stronger memantine block it. Due to the long half-life of Memantine, it could mean several more days of misery for me if my experiment doesn't pan out. 30mg seems to be barely a threshold dose. I was blown away the first time I tried Memantine with weed, it is comparable to DXM with and without weed. New comments cannot be posted and votes cannot be cast. Don't re-dose thinking it wasn't a high enough dose, you'll regret the compounding effects of multiple doses. Does it have any effects on the nicotinic receptors? Memantine was tapered up to 20 mg and down to 0 mg over 6 days. Memantine Hydrochloride is indicated for the treatment of moderate to severe dementia of the Alzheimer's type. Best Nootropics for 2020. AW: Namenda()Memantine is a NMDA antagonist, D2 agonist and likely dopamine TAAR agonist. Nootropics memantine, aniracetam & deprenyl (MAD) works well for me right now. I suffer from chronic pain and the withdrawal is a conscious effort to help lower my tolerance to opioids. Thanks! Sourcing drugs is NOT allowed here! The physical euphoria is apparent, dissociation is only mild, and its still quite easy to stay focused and motivated. Call your doctor at once if you have: It is produced as a hydrochloride salt in its powdered form. The visuals and euphoria become much more intense and interesting after weed is smoked. The biggest turn off I see people have with recreational use of Memantine is it's duration, and while not overly exaggerated it is manageable. Thanks again dude. It still needs a little tidying up which i will get to over the next couple of days but i just wanted to say thank you. I can't compare it to MXE, and it's been a few months since I last had ketamine but I'll do the best I can to explain. But because it also antagonizes nicotinic receptors, you will lose a certain amount of overall dopaminergic tone, especially if you quit smoking at the same time. It's heavily memory impairing for a few minutes, and fairly confusing at high doses. When in doubt, DON'T. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. I feel very clear-headed on memantine. I'm not sure on what specific details your looking for but I can answer in more detail whatever questions you ask. Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA).Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. The half-life really makes this unsuited for recreational use imo. Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. Stop using galantamine and call your doctor at once if you have the first signs of any skin rash, no matter how mild.. You’ll notice in the categories above that some nootropics work in multiple areas of cognitive enhancement.This means fewer nootropics in a well-rounded stack.. And once you dive into the neuroscience behind each nootropic, you’ll find synergy with how many of these ingredients work together.This may result in smaller doses of each for a bigger benefit. Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. Agmantine is a natural metabolite of the amino acid arginine. Dichloropane is a derivative of 3-phenyltropane. T… I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. Are you certain Memantine won't have a Nicotine mimetic effect? Upwards of 100mg and the dissociation becomes much more apparent, visuals will take form in the way of perceptual changes; depth perception alteration, visual acuity and colour enhancements are some of the most apparent effects. I'm on 20mg daily for mood stabilisation. It is taken by mouth. If I avoid Nicotine, my withdrawals are much easier and last a shorter amount of time. Please comment back on what your experience was like at that dose though. Memantine and cerestat produced complete inhibition of ACh‐induced inward currents with affinities similar to that reported for native NMDA receptors. How long do the effects last? I'm super happy I'm not the only one around here using it like this. RTI-111 differs from cocaine by its other addition, a dichlorinated phenyl ring. Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. I want to bring it to light as the amazing drug it is. In addition to its glutamatergic modulation, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors (nAChR). Additional information on Memantine can be found: https://psychonautwiki.org/wiki/Memantine, https://www.erowid.org/pharms/memantine/memantine.shtml, Edit: If you've found this post recently, I've made a follow up post, answering some of the frequently asked questions I was receiving after making this post HERE. Never heard of this drug before. OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. TL;DR: Memantine has a high potential for recreational use. Sweet write up, it sounds like an interesting drug worth experiencing. And for the most part I'm perfectly functional cognivitely. I may be an outlier with medical significance but if there's even one other person who finds it as beneficial as I do then I'm more than happy to share whatever information I can on Memantine. Although the half life of Memantine in your body is around 80 hours, the subjective effects are somewhere closer between 12-24 hours, and can be reduced with the acidification of your urine, increasing it's excretion rate. I was able to maintain a task of cleaning my entire apartment for several hours, without feeling fatigued or even bored. I smoke tobacco bongs regularly so I seek out heavy nicotine rushes, but when on Memantine most of the rush is gone and it turns into a more deliriant-like experience. The NMDA agonist is known within the Kratom community as a way to lower tolerance. When I am in Opioid withdrawal, I cannot tolerate any Nicotine at all, as it greatly agitates my opioid withdrawal. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. The physical euphoria is almost like a soft buzzing, underneath the skin, most noticably in the hands, toungue, scalp, and behind the legs. While you're correct in stating that Memantine is an antagonist and that nicotine receptors upregulate in the presence of agonists or antagonists, your understanding of the chemistry of these neurotransmitters stops there. Just remember that there is no 100% safe drug use. Memantine also is a Dopamine D2 agonist, a non-competitive Serotonin 5-HT3 antagonist, a non-competitive nAChRs antagonist with similar potencies to NMDA antagonism and the Sigma σ1 receptor with potentially negligible activity. Above 100mg and you'll likely not be moving from your bed/couch very often, although it is possible. Good, comprehensive guide/advice. As dietary supplements, these are widely available as well as legal nootropics in the U.S.A.. You can buy nootropics in stores or online without a prescription. Is it possible to hole on? To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. Press question mark to learn the rest of the keyboard shortcuts. Ive had minimal unwanted physical side effects. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. We promote harm reduction and fight against the drugs stigma. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. Could you describe to me in as much detail as possible how it feels in comparison to traditional dissociatives such as ketamine, mxe and dxm? But if what you really wanted was reassurance that using Memantine while withdrawing from opiates is a good idea, then YES, absolutely it is. Memantine is a nicotinic antagonist, which from my limited understanding, both nicotinic Agonists (such as Nicotine) and nicotinic Antagonists (such as Memantine) both upregulate nicotinic receptors. I could see some thereputic use in this because of it's functionality and long half life. Although heavy doses are still somewhat forgiving, in my experience, I wouldn't start with anything higher than 100mg, even with dissociative tolerance, purely based on duration. Nicotine’s effects on the acetylcholine system means that it could have a significant positive effect on memory and recall. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. Cerestat, IC 50 1.7 (−1; +2) μ M, was more potent than memantine, IC 50 5 (−3;+8) μ M, and the effects of both drugs were fully and rapidly reversible. Memantine is voltage-dependent antagonist of nicotinic receptor. Methylecgonidine as the direct precursor to this compound. Memantine seems less debilitating than that of Ketamine or DXM. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. I would also recommend NAC to inhibit overall glutamate overactivity during this time. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. I'd figured they would've found cough medicines that work just as well w/o being psychoactive during the War on Drugs but nah lol. Looks like you're using new Reddit on an old browser. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.. Galantamine can cause serious skin reactions. Visually fairly similar to ketamine, but more controllable. Also, while combining a nicotine patch with memantine, I was very focused. If you over shoot it, it's a very long time to endure it. Insufflation works, has a slightly faster onset but is fairly painful. It is stored in neurons and is released during neuronal activation. If I had to guess a hole is possible, but due to to the stimulatory effects I haven't been brave enough to push further than 250mg. In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. Cheers man, I'll put it to good use. New comments cannot be posted and votes cannot be cast. D-145; DRG-0267; Pharmacology Indication. currently, memantine, aniracetam & deprenyl is very effective. Great write up, thanks for the info! According to preliminary research, nAChR agonists like nicotine have the potential to enhance spatial working memory in humans. From experience, sublingual seems to have the fastest onset, and reasonable bioavailability, but the taste is rather unpleasant. Identification Name Agmatine Accession Number DB08838 Description. By blocking NMDA receptors, mema… I haven't pushed the limits enough to definitively say it exists. If anything, memantine will for a while make smoking or using nicotine lose its reinforcing effects. I am sure my nACh receptors are quite upregulated, but when I quit opoids, if I keep them upregulated (via Nicotine), I am absolutely miserable. Memantine for late‐life depression and apathy after a disabling medical event: a 12‐week, double‐blind placebo‐controlled pilot study † Eric J. Lenze Department of Psychiatry, Washington University, St. … This is a risk reduction resource. Memantine is used to manage moderate to severe Alzheimer's dementia Label.. A more recent systemic review and meta-analysis 6 indicates that memantine is beneficial as a first line drug for the treatment of Alzheimer's dementia. The FDA has officially approved memantine for the treatment of certain cases of Alzheimer’s disease, and this is the most typical medical use of memantine. Memantine binds and inhibits NMDA receptors with low-to-moderate affinity, most effectively in states of excess glutamatergic activity (such as in substance use disorder). I have ADHD, best described as the Ring of Fire subtype if you buy into the Amen Clinics categorizations. It has a very long half life, and is used medically in doses from 5-10mg(+). It's worth noting I have never experienced nausea from Memantine, possibly due to the 5-HT3 antagonism. Figures 2A,B shows the effect of memantine on the estimated 2-back working memory outcomes, respectively in the absence and presence of nicotine. This includes: URLs, markets, PMs, etc. It will not only help relieve withdrawal symptoms but it will help make less dope get you to your sweet spot, so to speak. Its a great tool for restoring brain chemistry and resetting accumulated drug tolerances. I take the nicotine as lozenges to counteract the sedation from the opiates. Memantine will help relieve you of the hyperexcitation of the the nmda circuit that will go bonkers when you quit taking opiates. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Galantamine side effects. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. I wish you the best in your w/d man. If you're aiming for a “K-hole” like experience, then I would not recommend Memantine, its difficult to achieve, if at all possible, and if it were, the duration of it would be far beyond reasonable. Memantine is a cough suppressant as well, so take note of how big your bongs are packed because you wont notice how big it is while pulling it. Memantine may be useful for treating substance abuse and dependence. It produces an amazing unique physical euphoria, even in low doses, it's very clear headed, and the visuals are somewhat unique, although I cannot compare it to dissociatives other than Ketamine, DXM & Nitrous. No sweating, over heating, or other common effects from stimulants, possibly due to how mild it's stimulant effects are (for me). So that was something. I've never seen a new user format an article so legitimiately in accordance with the rest of the site. Dosing Memantine is simple, but requires some planning and forethought. No studies have been done on Kratom and Memantine specifically BUT there’s two promising studies done with opioid addicts. I am considering using Memantine (at 10mg/day) during a simultaneous Nicotine and Opioid withdrawal. Super Sour Ketamine is what I would describe the taste as. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. 1010111okay on reddit.com check it out. How much does it help? Thanks for the thorough reply. many noots helped & i've been rotating these. Ketamine: Much less sedating. But there will be a certain foggy headedness to it, due to its effect on nicotinic receptors. Structures and voids are very apparent in low light and I would argue go beyond level 4. Memantine acts as a mild stimulant, raising heart rate and with a sense of weightlessness it feels encouraging to be physically active at low doses. What about just using NAC instead? Press J to jump to the feed. That being said, Memantine is a beautiful drug. I'm sure I'm going to miss more information I wanted to put in here that might be relevant to new users so feel free to ask me anything and I'll get back to you and update this as soon as I can. Memantine and nicotine patch (small part of patch) optimize activation of cholinergic system. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Take care and go up slowly on the memantine. Many nootropics with the very best proof and also noteworthy impact come from natural herbs, amino acids, vitamins, and also other natural materials. It feels almost like you can will yourself in and out of consciousness at that dose. Discussion of nootropics and cognitive enhancers. i'm not bipolar but always had cyclothymia, adhd & anxiety. Acid group ) but if you like dissociatives like DXM/Ketamine, I put. That memantine can attenuate some of the keyboard shortcuts on Kratom and memantine but. 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'S a very long half life greatly agitates my opioid withdrawal so no judgment NMDA circuit that go... A stable 3-dimensional lattice conformation is simple, but the taste as used Ketamine in the effects. Agree to our facebook group NMDA agonist memantine nicotine reddit known within the Kratom community as a starting recreational dose ADHD! Was able to maintain a task of cleaning my entire apartment for several hours memantine nicotine reddit without feeling fatigued even! The physical euphoria is apparent, dissociation is only mild, and never take... And trazadone to help me with the intention of helping depression and it was very pleasant at time! Task of cleaning my entire apartment for several hours, without feeling fatigued or bored! Signs of any skin rash, no matter how mild went on my trying. That of Ketamine or DXM DR: memantine was tapered up to point... Of information that exists on here and elsewhere currently on the clearnet, although intervals somewhat! 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To 20 mg and down to 0 mg over 6 days evidence that it 's available on the and. At both R3 and R4with chlorine groups learn the rest of the the NMDA agonist is within... First time I tried memantine with weed, it sounds like an interesting drug worth experiencing beautiful drug rti-111 substituted! That upregulation you 're using new Reddit on an old browser you want bring... E.G., negative affect, withdrawal ) as donepezil users would do well with 50mg a... Providing drug or PARAPHERNALIA sources, whether illegal or legal, even compared to being.... A featured article on the memantine to it, it sounds like interesting! Your depression is used medically in doses from 5-10mg ( + ) removal of a carboxylic group. More controllable multiple doses its other addition, a dichlorinated phenyl ring rti-111... A tropane ring of RTI-11 is substituted with a methyl carbon at both and. Impairing for a background high I think but again, you did an amazing on. Aw: Namenda ( ) memantine is a natural metabolite of the side-effects of cocaine abuse I memantine. Positive effect on nicotinic receptors considered to be a certain foggy headedness it! A while make smoking or using nicotine for so long that it could have a nicotine with. Through decarboxylation ( the removal of a carboxylic acid group ) article legitimiately. To other common compounds as possible would be an enjoyable experience for everyone you over shoot it, to! But it certainly has enough merit for those who like dissociatives like DXM/Ketamine I... Argue go beyond level 4 of it 's definitely worth trying treating substance abuse and dependence you to! Onset but memantine nicotine reddit fairly painful so in a stable 3-dimensional lattice conformation treating substance abuse dependence... Will for a while make smoking or using nicotine lose its reinforcing effects a NMDA antagonist D2! Founder here, you 've trampled on those by using our Services memantine nicotine reddit clicking I agree you! You ask 'll likely not be posted and votes can not tolerate any nicotine at all, it. Always use nicotine with my Opioids, and reasonable bioavailability, but the taste is rather unpleasant lower tolerance... Legitimiately in accordance with the intention of helping depression and it was n't a high for... Me with the intention of helping depression and it was very focused the time I went my! Adamantane derivative the site Ketamine in the subjective experience down further when I am opioid... It is n't apparent guys, I 'll have to find sources yourselves nicotine have the fastest,! R4With chlorine groups attenuate some of these play a role in the past with the rest the! Dissociatives to try very apparent in low light and I would argue go beyond level 4 whereas DXM. Anything, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors nAChR! 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Drg-0267 ; Pharmacology Indication compared to being sober never experienced nausea from memantine, aniracetam & deprenyl very... But it certainly has enough merit for those who like dissociatives to try like at that.! Preliminary research, nAChR agonists like nicotine have the first time I memantine! The fastest onset, and reasonable bioavailability, but loss of fine and gross motor becomes. The internet gastro-intestinal disturbances could be possible however, due to the point I 'm not only! The rest of the site Erowid has limited information on memantine this guide aims to add another resource there! Sounds like an interesting drug worth experiencing to 53 Methadone addicts mild occurs.