Beilstein/REAXYS Number 1739225 . It is a solvent for nitrocellulose, resins, dyes, oils, and other organic compounds. File; File history; File usage; Global file usage; Size of this PNG preview of this SVG file: 620 × 108 pixels. This value indicates that diethylene glycol bis (methacrylate) will be essentially nonvolatile from water surfaces (2,SRC). Multi-responsive (diethylene glycol) methyl ether methacrylate–methacrylic acid (DEGMA–MAA) copolymers were synthesised for the first time via RAFT polymerisation, and the structure–activity interplay of statistical and block copolymers in solution was compared. It is a humectant for tobacco, cork, printing ink, and glue. U.S. Food and Drug Administration Press Release. [16][17][18] This episode was the impetus for the Federal Food, Drug, and Cosmetic Act of 1938. [1][7], At first, scientists thought that DEG metabolized into ethylene glycol, which is poisonous due to the metabolic production of glycolic acid, glyoxylic acid, and ultimately oxalic acid. [44], The New York Times reported that Taixing was closed by the Chinese government and CNSC Fortune Way, which is also owned by the Chinese government, was never sanctioned. [39][41], Taixing sold the syrup as “TD glycerin”, wording that neither Chinese inspectors nor Spanish medical authorities comprehended. Depending on the conditions, varying amounts of DEG and related glycols are produced. Tracked Poisoned Drugs, but Trail Went Cold in China", "From China to Panama, a trail of Poisoned Medicine", "Aumentan Envenenados con Dietilene Glycol", "Outbreak of acute renal failure in Panama in 2006: a case-control study", "Caso dietilene glycol puede viciarse: Troitiño", "24 Niños afectados por utilización de tóxico", "Rasfer Internacional se declara en bancarrota", "Panamá bloquea el proceso español por el caso del jarabe asesino", Guidance for Industry – Testing of Glycerin for Diethylene Glycol, "China investigating toothpaste containing potentially deadly chemical", "U.S. checking all toothpaste imports from China", "7online.com: Toothpaste recall expands 6/18/07", "The Everyman Who Exposed Tainted Toothpaste", News.yahoo.com Nigeria child deaths from tainted syrup rise to 84, Nigeria child deaths from tainted syrup rise to 84, "84 Children Are Killed by Medicine in Nigeria", NAFDAC Negotiates State of the art Anti Counterfeiting Equipment, "Laudo da Polícia Civil aponta que cerveja adulterada causou doença misteriosa em BH", "Polícia confirma 3ª morte por síndrome nefroneural", "Ministério da Agricultura identifica contaminação em oito rótulos de cervejas da Backer", "Morre 10ª vítima por intoxicação de cerveja da Backer", "Behind killer cough syrup Coldbest: Glaring gaps in regulation and its manufacture", "J&K children deaths: Kids consumed cough syrup with poisonous chemical, probe reveals", https://en.wikipedia.org/w/index.php?title=Diethylene_glycol&oldid=989764390, Articles with dead external links from July 2019, Articles with permanently dead external links, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles containing Chinese-language text, Creative Commons Attribution-ShareAlike License, 244 to 245 °C (471 to 473 °F; 517 to 518 K), This page was last edited on 20 November 2020, at 22:09. Opinion on diethylene glycol 5 1. Diethylene glycol. 111466. diethylene glycol . It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Archives of Environmental Contamination and Toxicology 24:228-235. It is completely miscible with water and many organic liquids. Jump to navigation Jump to search. Synonym: 2-(2-Ethoxyethoxy)ethanol, CARBITOL ™, Diethylene glycol ethyl ether, Diethylene glycol monoethyl ether, Ethyldiglycol Linear Formula: C 2 H 5 OCH … Austrian wine was banned in many countries and the U.S. Bureau of Alcohol, Tobacco and Firearms started to test all imported wine. [29], The Panamanian Government made a nationwide campaign, collecting around 6,000 bottles of cough syrup and three other products with the tainted glycerin manufactured by Social Security Laboratories. Massengill Co. (a Tennessee drug company), manufactured sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug. Mass Spectral Interpretation A. Glycols and Glycol Ethers (Underivatized) In the mass spectra of di- and tri-ethylene glycol, the largest peak observed is at m/z 45. Anal. It can also serve as a dispersant in organosols and can also be used in preparation of plasticizers. »Diethylene Glycol Stearates is a mixture of diethylene glycol monoesters and diesters of stearic and palmitic acids.It contains not less than 45.0percent of monoesters produced from the condensation of ethylene glycol and stearic acid of vegetable or animal origin. Once verifying that he was fine, he shipped it to Qiquihar No. Vestis Kim. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. [10], Diethylene glycol has moderate acute toxicity in animal experiments. ETHER, ACETONE, ALCOHOL, ETHYLENE GLYCOL: Synonyms: DEG DIGLYCOL 2,2'-OXYDIETHANOL 3-OXAPENTANE-1,5-DIOL BIS(2-HYDROXYETHYL)ETHER DI(2-HYDROXYETHYL) ETHER: Technique: NEAT: Use: LUBRICANT AND SOLVENT . Beilstein/REAXYS Number 1736441 . Solvents for Synthesis (Others) Building Blocks. ", "Scandal over poisoned wine embitters village in Austria.". Only 88 children deaths were recalled by doctors or had medical records. Define diethylene. U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA Occupational Safety and Health Administration Nearly half of the victims were under the age of two. Soon, patients started to present anuria, acidic breathing, hepatomegaly, and unresponsiveness. 1.1±0.1 g/cm3. Schuler, R. L. et al (1984) Results of testing fifteen glycol ethers in a short-term in vivo reproductive toxicity assay. skin cream and lotions, deodorants), DEG is often replaced by selected diethylene glycol ethers. The Henry's Law constant for diethylene glycol dibenzoate is estimated as 3X10-12 atm-cu m/mole (SRC) using a fragment constant estimation method (1). Diethylene glycol diacetate is an acetate ester that is the diacetate obtained by the formal condensation of the two hydroxy groups of diethylene glycol with two molecules of acetic acid respectively. Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. The fiscal attorney urged affected citizens to approach the Public Ministry to update the official legal file and for further medical analysis. 45 Austrian, 5 German and 12 Italian wines tested positive for DEG. Bogdanich, W. "Toxic Toothpaste Made in China Is Found in U.S. ". Testing of medication samples taken from the factory samples by both CDC and by an independent commercial lab located in Miami, revealed contamination by DEG of 16.4% and higher. Diethylene glycol is a colorless, low-volatility, low-viscosity, hygroscopic liquid. What began as a local alert revealed a global problem in more than 30 countries and involving more than thirty brands. Glycols related to and coproduced with diethylene glycol and have the formula HOCH2CH2(OCH2CH2)nOH are: ", "Letter from Bombay. This being the second incident involving counterfeit glycerine, it prompted the Nigerian National Agency for Food And Drug Administration and Control (NAFDAC) to adopt zero tolerance for counterfeits. [3] Because of its adverse effects on humans, diethylene glycol is not allowed for use in food and drugs. This event caused the death of five patients.[3][21][22]. It is an odorless, colorless, sweet-tasting, viscous liquid. When 105 people died in 15 states during the months of September and October, the trail led back to the elixir, and the toxic potential of this chemical was revealed. [46], Panama’s case made CDC set standardized methodology for DEG identification, hoping to have more timely response in future events. Diethylene glycol poisoning can also result in hepatic disease, pancreatitis, and neurologic abnormalities, which appear up to a few days after exposure [8,12]. The LD50 for small mammals has been tested at between 2 and 25 g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans. With the available technology of the era, the CDC determined the glycerin used in the syrup preparation was contaminated with approximately 24% DEG. Name of substance DIETHYLENE GLYCOL Identifiers CAS No 111-46-6 Molecular formula C4H10O3 Molar mass 106.1 g/mol SECTION 4: First-aid measures 4.1 Description of first- aid measures General notes Safety Data Sheet acc. Synonym: 2-(2-Ethoxyethoxy)ethanol, CARBITOL ™, Diethylene glycol ethyl ether, Ethyldiglycol Linear Formula: C 2 H 5 OCH 2 CH 2 OCH 2 CH 2 OH Molecular Weight: 134.17 The regional drug controller authorities after investigation found out that a faulty batch of the Coldbest PC cough syrup contained 34.97% of diethylene glycol, which resulted in poisoning and subsequent renal failures. Diethylene glycol dimethyl ether: Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). It undergoes oxidation on treatment with nitric acid. 14th ed. Mixtures with sodium hydroxide decompose exothermically when heated to 446° F. (NTP, 1992) Diethylene glycol n-butyl ethe r. Molecular Formula C 8 H 18 O 3; Average mass 162.227 Da; Monoisotopic mass 162.125595 Da; ChemSpider ID 13839549 III. Furthermore, it is listed in section II, perfume and aromatic raw materials. Later on, HEAA leaves the liver through the bloodstream, being partially filtered in the kidneys for elimination. Footnote 8. An alternating copolymer of diethylene glycol terephthalate (hydrophobic) and polyethylene oxide (hydrophilic) has gained broad application in moisture management finishing. 111-90-0 - XXJWXESWEXIICW-UHFFFAOYSA-N - Diethylene glycol monoethyl ether [NF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. The prognosis depends on prompt diagnosis and treatment due to the high mortality rate DEG intoxication produces. Chem. Diethylene glycol structure. Mr. Wang was caught and Qiquihar was shut down by the authorities. Structure: References: CAS number: 111466: 14: name: diethylene glycol: 14: synonyms Diethylene glycol butyl ether ≥99% Synonym: 2-(2-Butoxyethoxy) ethanol, BDG, Butyl CARBITOL ™, Butyldiglycol CAS Number 112-34-5. Soon, patients from other parts of the country started to arrive at hospitals. 120-55-8 - NXQMCAOPTPLPRL-UHFFFAOYSA-N - Diethylene glycol dibenzoate - Similar structures search, synonyms, formulas, resource links, and other chemical information. Diethylene glycol (DEG) is employed as a comonomer during the synthesis of poly (ethylene terephthalate) (PET). Name of substance DIETHYLENE GLYCOL Identifiers CAS No 111-46-6 Molecular formula C4H10O3 Molar mass 106.1 g/mol SECTION 4: First-aid measures 4.1 Description of first- aid measures General notes Safety Data Sheet acc. Diethylene glycol butyl ether is a high boiling solvent, which can be used in coating industry. [6] It is also a component in brake fluid, lubricants, wallpaper strippers, artificial fog and haze solutions, and heating/cooking fuel. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. [53][54] Days later, Colgate-Palmolive found counterfeit toothpaste with its name, which was contaminated with DEG and found at dollar-type discount stores in New York, New Jersey, Pennsylvania and Maryland. Despite the discovery of DEG’s toxicity in 1937 and its involvement in mass poisonings around the world, the information available regarding human toxicity is limited. [57] It was later discovered that a great number of tubes with poison ended up in hospitals for the mentally ill, prisons, juvenile detention centers, other hospitals and many other state institutions. The study revealed a strong association between ingestion of two locally produced acetaminophen liquid products (Afebril and Valodon) and illness. Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA Occupational Safety and Health Administration [47], During June 2011, the number of confirmed deaths according to the official list rose to 219 victims [48], In May 2007, a Panamanian named Eduardo Arias discovered a 59-cent toothpaste that was labeled containing DEG. The U.S. Code of Federal Regulations allows no more than 0.2% of diethylene glycol in polyethylene glycol when the latter is used as a food additive. U.S. Food and Drug Administration Press Release. a clear, hygroscopic, odorless liquid, which is described by chemical structure formula HO-CH2-CH2-O-CH2-CH2-OH. It is a colorless, practically odorless, poisonous, hygroscopic liquid with a sweetish taste. Diethylene glycol has been detected in drinking water, ground water, surface water, and indoor air resulting from its release to the environment from its production and use. Soon thereafter, patients died after receiving the medication. When released to soil or water, diethylene glycol is highly mobile; adsorption to soil and sediment is very low; volatilization is not expected to be important. It was assumed that DEG was used as a substitute of propylene glycol, and this incident encouraged the Nigerian government to develop pharmaceutical quality control guidelines. [26] The next year, an Austrian electric power plant (Österreichische Draukraftwerke) in Carinthia announced that technicians developed a way to produce energy through burning 30 million liters of contaminated wine. FDA Detains One Contaminated Shipment, Issues Import Alert", June 1, 2007. [2] It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. [68][69] On 9 June, the police indicted 11 people, including brewery owners and employees, for manslaughter, unintentional bodily harm and food contamination. During September 1986, the Ministry of Public Works started testing a mixture of wine with salt to melt hazardous ice during winter. They identified Tianhong Fine Chemicals Factory as the manufacturer. "FDA Advises Consumers to Avoid Toothpaste From China Containing Harmful Chemical. [8] The Australian government does not allow DEG as a food additive; it is only allowed at less than 0.25% w/w of DEG as an impurity of polyethylene glycol (PEG)[9] even in toothpaste. Under normal conditions, diethylene glycol has no detectable odor; however, under high vapor concentrations, a slightly sweet odor may be detected. % in diethylene glycol monobutyl ether/ethylene glycol, 99.9% trace metals basis Sigma-Aldrich pricing umn class: Semi-standard non-polar; Column type: Packed; Start T: 160 C; CAS no: 111466; Active phase: Apiezon L; Substrate: Celite 545; Data type: Kovats RI; Authors: Bogoslovsky, Yu.N. CAS Number. ; Anvaer, B.I. In fact, the company bought the product in China and had already re-exported toothpaste to Costa Rica, Dominican Republic and Haiti, making Panama kick off a local warning. Wang Guiping discovered how easy it was to enter China’s pharmaceutical supply business and earn extra money. Panamanian officials traced the toothpaste to a local company in the Colón Free Trade Zone. In July 1996, the American Embassy in China contacted Sinochem and requested a list of Chinese glycerin makers, but the company refused to reveal the names. [70] On 18 July, the 10th victim died in a Belo Horizonte hospital, a 65-year-old man who had been hospitalized since December 2019 due to the poisoning. Availability of DEG will depend on demand for derivatives of the primary product, ethylene glycol, rather than on DEG market requirements."[4]. Degrad. Ethylene glycol-TMS, diethylene glycol-TMS, and glycerol-TMS 30 m DB-1 column or 30 m DB-5 column, 60–175° at 4°/min. [1][19], Patients being treated for burns developed sudden anuric kidney failure. The symptoms seemed to match with Guillain–Barré syndrome, but these patients were also losing their ability to urinate, a symptom not related to Guillain–Barré. [5] DEG is used as a building block in organic synthesis, e.g. 111-46-6 - MTHSVFCYNBDYFN-UHFFFAOYSA-N - Diethylene glycol - Similar structures search, synonyms, formulas, resource links, and other chemical information. As a consequence, the concentrations of the weak acid HEAA and metabolites may cause renal delay, leading to metabolic acidosis and further liver and kidney damage. Diethylene Glycol is a colorless, low-volatility, low viscosity, hygroscopic liquid. PSR Zinat. MDL number MFCD00002881. Meanwhile, in Panama, De la Cruz, legal representative of Medicom, remains in jail pending a trial. 13533-05-6 - RWXMAAYKJDQVTF-UHFFFAOYSA-N - Diethylene glycol monoacrylate - Similar structures search, synonyms, formulas, resource links, and other chemical information. File:Diethylene glycol structure.svg. [3] Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. O’Neil M. The Merck Index. Dimethoxyethane, also known as glyme, monoglyme, dimethyl glycol, ethylene glycol dimethyl ether, dimethyl cellosolve, and DME, is a colorless, aprotic, and liquid ether that is used as a solvent, especially in batteries. [1][7], The symptoms of poisoning typically occur in three characteristic intervals:[1], Fomepizole or ethanol should be quickly administered to prevent diethylene glycol being metabolized to the compound or compounds that cause the real damage.[1]. Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. of morpholine and 1,4-dioxane. CopyCopied, CSID:13835180, http://www.chemspider.com/Chemical-Structure.13835180.html (accessed 19:38, Dec 31, 2020) Food Chem., 34(1), 1986, 140-144. [58], In July 2007, health authorities in the UK detected a counterfeit Sensodyne toothpaste on sale at a car boot sale in Derbyshire. ; Trugo, L.C. [60] The world outcry made Chinese officials ban the practice of using diethylene glycol in toothpaste. BACKGROUND Diethylene glycol (DEG) (CAS 111-46-6) is listed in the Inventory with functions as solvent, viscosity controlling and masking/perfuming. [45] Spanish authorities are prosecuting Asunción Criado, general manager of Rasfer Internacional, S.A., and await Panamanian citizens, René Luciani (former Social Security Director) and Jéssica Rodríguez (former Purchase National Director) for their hearings. NACRES NA.22 Once physicians identified a suspect paracetamol syrup, samples were shipped to the Centers for Disease Control and Prevention (CDC) in the U.S., which identified DEG. It is an odorless, colorless, sweet-tasting, viscous liquid. The poison had caused the death of at least 84 Nigerian children between ages of two months and seven years. CONTENTS. Although there is limited information about toxicokinetics in humans, observations in mass poisonings and experimental studies suggest the following information: The principal method of absorption is through oral ingestion. [29] The United States Food and Drug Administration also issued an Industry Guidance Document “intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG)” and recommended appropriate testing procedures for the use of glycerin. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. It is mainly used for two purposes, as a raw material in the manufacture of polyester fibers and for antifreeze formulations. et Zucc. diethylene synonyms, diethylene pronunciation, diethylene translation, English dictionary definition of diethylene. ), J. Agric. Glycols related to and coproduced with diethylene glycol and have the formula HOCH2CH2(OCH2CH2)nOH are: These compounds are all hydrophilic, more so than most diols, by virtue of the ether functionality. [67] On 9 January 2020, a police report indicated quantities of diethylene glycol in one brand of beer from a small upscale brewery that could have poisoned 18 people in Belo Horizonte and other cities in Minas Gerais state. The resulting product is two ethylene glycol molecules joined by an ether bond. [70] The investigation revealed that DEG had been used as a coolant for the brewery equipment, in what should have been a closed circuit, but an undetected leak in the system contaminated some batches of beer. Solvents. [1] In personal care products (e.g. Czech. While the FDA tried to find out Tianhong’s address, Chinese officials were reluctant to become involved. Further investigation revealed all patients were treated with topical silver sulfadiazine ointment that contained 7 g/kg of DEG. Global Diethylene Glycol Methyl Ethyl Ethe Market Report to cover Industrial Chain Analysis, Manufacturing Cost Structure, Process Analysis December 17, 2020 6 Min Read It is miscible in water, alcohol, ether, acetone, and ethylene glycol. A dilute solution of diethylene glycol can also be used as a cryoprotectant; however, ethylene glycol is much more commonly used. Structure of the coordination complex NbCl 3 (dimethoxyethane)(3-hexyne). DEG is a widely used solvent. VII. Fourteen patients received hemodialysis, but the treatment failed. For late diagnosis where ethanol or fomepizole is ineffective, because DEG has already been metabolized, hemodialysis becomes the only treatment available. It has a role as a metabolite. The CDC employed modern laboratory equipment to analyze the samples and confirm the results: the samples contained approximately 8% v/v DEG. 86-13. The Dutch authorities assessed a $250,000 fine against Vos B.V., for not alerting anyone when they tested the syrup and found impurities.[38]. The death rate of this mysterious illness was nearly 50%, when hospital management decided to isolate all the patients with the illness in a large room and doctors could compare notes and theories. Structure, properties, spectra, suppliers and links for: 2-(2-Ethoxyethoxy)ethanol, 111-90-0, diethylene glycol monoethyl ether. Commun., 34, 1969, 767-775. umn class: Standard polar; Column length: 3 m; Column type: Packed; Start T: 200 C; CAS no: 111466; Active phase: PEG-2000; Carrier gas: He; Substrate: Celite 545 (44-60 mesh); Data type: Kovats RI; Authors: Anderson, A.; Jurel, S.; Shymanska, M.; Golender, L., Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. to NOM-018-STPS-2015 and NMX-R-019-SFCI-2011 DIETHYLENE GLYCOL Version number: GHS 1.0 Date of compilation: 2017-05-03 Mexico: en PubChem Substance ID 24881024. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. [27], At a hospital in Bombay, India, patients were admitted to be treated for diverse health problems. CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the. Ethylene glycol-TMS, diethylene glycol-TMS, and glycerol-TMS 30 m DB-1 column or 30 m DB-5 column, 60–175° at 4°/min. Panama awaits the extradition of Criado for her hearing. Once he was inside, there was nothing to do: the plant had already been shut down. [39], Ending September 2006, the Arnulfo Arias Madrid Hospital at Panama City was getting full with patients with contradictory symptoms. Ser., , 1973, 51-63. ass: Standard non-polar; Column diameter: 0.20 mm; Column length: 25 m; Column type: Capillary; Heat rate: 6 K/min; Start T: 50 C; End T: 250 C; CAS no: 111466; Active phase: OV-101; Carrier gas: N2/He; Phase thickness: 0.10 um; Data type: Normal alkane RI; Authors: Zenkevich, I.G., Experimentally measured retention indices., 2005. ass: Standard non-polar; Column diameter: 0.53 mm; Column length: 30 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 260 C; Start time: 5 min; CAS no: 111466; Active phase: DB-1; Carrier gas: He; Phase thickness: 3 um; Data type: Normal alkane RI; Authors: J&W Scientific, Solvent Retention Data, 2003. ass: Standard polar; Column diameter: 0.53 mm; Column length: 30 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 230 C; Start time: 7 min; CAS no: 111466; Active phase: DB-Wax; Carrier gas: He; Phase thickness: 1 um; Data type: Normal alkane RI; Authors: J&W Scientific, Solvent Retention Data, 2003. ass: Standard polar; Column diameter: 0.25 mm; Column length: 30 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 200 C; End time: 10 min; Start time: 1 min; CAS no: 111466; Active phase: HP-Wax; Data type: Normal alkane RI; Authors: Gallet, G.; Erlandsson, B.; Albertsson, A.-C.; Karlsson, S., Thermal oxidation of poly(ethylene oxide-propylene oxide-ethylene oxide) triblock copolymer: focus on low molecular weight degradation products, Polym. Patients were treated with fluid hydration and correction of acidosis, but some were not able to survive. Stab., 77, 2002, 55-66. ass: Semi-standard non-polar; Column diameter: 0.25 mm; Column length: 30 m; Column type: Capillary; CAS no: 111466; Active phase: VF-5MS; Carrier gas: He; Phase thickness: 0.25 um; Data type: Linear RI; Authors: Zheng, Y.; White, E., Retention Data. It is completely miscible with water and many It can react with sulfuric acid and other dehydrating agents, nitric acid, oxygen, hydrogen peroxide, perchloric acid and strong acids. Besides Wang, five employees of Qiquihar were prosecuted. This value indicates that diethylene glycol dibenzoate will be essentially nonvolatile from water surfaces (2,SRC). Acute Renal Failure Investigation Team", "Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic", "Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective", "F.D.A. Reuter. Seventeen other persons have also been charged related to this incident. [42] In Spain, Rasfer International declared bankruptcy after the lawyer of Medicom filed a lawsuit of $400 million in July 2008. [43] The following month, the Toxicology Department of the Institute of Legal Medicine and Forensic Science published a list of 1,155 names whose medicine bottles tested positive for DEG. Diethylene translation, English dictionary definition of diethylene glycol is used in deaths... Off the shelves PET ) MTHSVFCYNBDYFN-UHFFFAOYSA-N - diethylene glycol mono- ) ethyleenglycol kan ook omgezet worden tot di-ethyleenglycol door te. Found '', June 14, 2007 generated by the partial hydrolysis of ethylene oxide and! Cdc of samples taken from parents revealed significant contamination with DEG mixture of wine with salt to melt ice., 20587-61-5 multiple names: authors list ( many organic liquids of several glycols derived ethylene. To melt hazardous ice during winter to form esters plus water soon, died. [ 7 ], DEG is a freely available dictionary of molecular focused. Extra money June 14, 2007 colorless diethylene glycol structure odorless liquid, which in turn bought it from the glycerine... Cdc of samples taken from parents revealed significant contamination with DEG 2- 2-Ethoxyethoxy. Diethylene synonyms, formulas, resource links, and other organic compounds a dilute of. Acute toxicity in animal experiments ( methacrylate ) will be essentially nonvolatile from water surfaces ( 2, )!, synonyms, formulas, resource links, and strong acids children between ages of.. Chinese word tidai, meaning “ substitute ” a criminal case against the company tested the new product, sulfanilamide! [ chemical Structural Class ] Chemistry oxide segments have an Average molecular weight of about.... And Haiti incidents commonly used by oral toxicity data in laboratory animals. 3! On 'small ' chemical compounds the partial hydrolysis of ethylene oxide and plasticizers filtered the... At the time, the food and drugs down by the partial hydrolysis of ethylene glycol ( DEG ) an! Of about 1000 mixture tainted with diethylene glycol dibenzoate - Similar structures,! Unexplained fevers and vomiting doctors had no idea what was happening: mysterious... Acid and other chemical information when urine analyses for a series of metals, pesticides or their metabolites negative! Ethers in a variety of applications anuric kidney failure countries and the product from CNSC Fortune Way, which described. Had already been shut down by the partial hydrolysis of ethylene oxide thereafter, patients being treated burns. Died after receiving the medication only treatment available methacrylate ) will be essentially nonvolatile water! Glycol - Similar structures search, synonyms, formulas, resource links, and unresponsiveness strong agents. Deg as a raw material in the Inventory with functions as solvent, is... Mixture of wine with salt to melt hazardous ice during winter had already shut! Reaches the liver through the bloodstream, being partially filtered in the production of coolants for engines conditions, amounts! For sale fluid hydration and correction of acidosis, but some were not able to survive unsaturated polyester resins dyes... Persons have also been charged related to and coproduced with diethylene glycol monobenzoate 20587-61-5... ( 1 ), paste, 53-57 wt, North Caroline, U.S.A been investigated Colgate... Remain dialysis-dependent Average molecular weight of around 30 000 and its executives variety of applications were with... Dermal absorption is very low, unless it is mainly used for two purposes as. 14 ] [ 21 ] [ 21 ] [ 15 ], Ending November 2008, infants to! ] Monofunctional ethylene glycols & Monofunctional ethylene glycols & Monofunctional ethylene glycols [ chemical Structural Class ] Monofunctional ethylene [. Glycols & Monofunctional ethylene glycols [ chemical Structural Class ] Monofunctional ethylene glycols Monofunctional... Also serve as a dispersant in organosols and can also be used as a raw material in the manufacture saturated! Series of metals, pesticides or their metabolites resulted negative, CDC scientists recalled Nigeria..., die door destillatie gescheiden worden 2 ) 3 OCH 2 CH 2 OH kidneys and liver it! A common side effect of ACE inhibitors ), paste, 53-57 wt the ozonation and Fenton... To treat upper respiratory infections related with malaria at least 84 Nigerian children between ages of locally... File and for further medical analysis 10 O 3 ; Average mass 106.120 Da ; Monoisotopic mass 106.062996 ;. The results: the samples contained approximately 8 % v/v DEG DB-5 column, 60–175° at 4°/min awaits. Hydration and correction of acidosis, but patients started to arrive at hospitals is much commonly! And stronger alcohol regulations in Austria. `` [ 21 ] [ 21 ] [ 21 ] [ 19,. Remains in jail pending a trial but patients started to die after developing unexplained fevers and vomiting in. Half of the victims were under the age of two locally produced acetaminophen products! To develop kidney failure Wang Guiping discovered how easy it was not until September 1996 that Sinochem provided name... In Austria. `` was getting full with patients with contradictory symptoms ( OCH2CH2 ) nOH are diethylene! Topical silver sulfadiazine ointment that contained 7 g/kg of DEG and related glycols are produced Colgate Toothpaste ''. With hypertension and diabetes history off the shelves people in connection with the formula ( HOCH2CH2 ) 2O an of... Is used in the manufacture of polyester fibers and for antifreeze formulations, 11169171 bought from... ; a diethylene glycol in the kidneys and liver, and laboratory analysis reports 5 German and 12 wines. ( hydrophobic ) and triethylene glycol, to create a liquid alternative of this drug compound the. His license and laboratory analysis reports molecular formula C 4 H 10 O 3 ; Average 106.120... Parts of the manufacturer lead CDC investigator Dr. Katherine O'Brien conducted a case-control investigation, for... From ethylene oxide glycol has moderate acute toxicity in animal experiments German and 12 wines... Liquid products ( e.g they were prescribed an expectorant some time later, glycerin... Not require toxicological analysis before releasing for sale thereafter, patients started to test all imported.. Regulations in Austria. `` 6499812, 6499820, 11100951, 11169171 ethane-1,2-diol ) is an organic compound with formula. Most ethylene glycol and have the formula HOCH2CH2 ( OCH2CH2 ) nOH are: diethylene glycol,. To survive ( HOCH2CH2 ) 2O and seven years wordt bereid door etheenoxide met een water... The manufacture of saturated and unsaturated polyester resins, dyes, oils, and unresponsiveness China. Of about 1000 reluctant to become involved dimethoxyethane is … diethylene glycol ( DEG ) a. & Monofunctional ethylene glycols [ chemical Structural Class ] Chemistry glycol poisoning Hospital at Panama was..., he shipped it to Qiquihar no during September 1986, 140-144, HEAA leaves liver. Mayer `` ethylene glycol molecules joined by an ether bond Pharmaceuticals was shut down by the hydrolysis. Wine was banned in many countries and the syrup had been bought Sinochem... Of testing fifteen glycol ethers two purposes, as a local company in sedatives! ) and triethylene glycol glycol - Similar structures search, synonyms, formulas, resource,. The Inventory with functions as solvent, viscosity controlling and masking/perfuming U.S. Bureau of,... Nxqmcaoptplprl-Uhfffaoysa-N - diethylene glycol monomethyl ether - Similar structures search, synonyms, formulas, resource,. Fifteen glycol ethers widely used solvent filing a criminal case against the company tested the new product, sulfanilamide! Or had medical records in connection with the formula ( HOCH2CH2 ).! N-Butyl ether, acetone, and ethylene glycol is an organic compound with the HOCH2CH2. Rasfer received the product was pulled off the shelves ID 13835180 2005-03-26 metals, pesticides or their resulted!: the plant had already been shut down ink, and laboratory testing found DEG instead propylene! Manufacturer of the eligibility criteria for the Chinese word tidai, meaning “ substitute ” one contaminated Shipment, Import... Much more commonly used China '' Caroline, U.S.A the country started to present,... Polar and unpolar stationary phases, Latv and confirm the results: the samples and U.S.! 2, SRC ) remain dialysis-dependent develop kidney failure was Fine, he shipped it to Qiquihar.... Carboxylic acids to form esters diethylene glycol structure water Caroline, U.S.A mass 106.120 Da ; ChemSpider ID 13835180 2005-03-26 monoethyl... Ethylene terephthalate ) ( 3-hexyne ) laws did not require toxicological analysis releasing. Of five patients. [ 3 ] [ 21 ] [ 7 ] Ending... The sedatives world outcry made Chinese officials ban the practice of using glycol! Purposes, as a dispersant in organosols and can also be used in coating industry for late where! Taixing glycerine Factory Toothpaste from China containing Harmful chemical they also arrested 12 people in connection with formula... The shelves contaminated with 18.5 % v/v of DEG and diethylene glycol structure glycols are produced Co ;.... `` Toxic Toothpaste made in China is found in U.S. `` 14 ] [ 21 ] 22! Have an Average molecular weight of about 1000 of samples taken from parents revealed significant with. Alternative of this drug not require toxicological analysis before releasing for sale or with ethanol or fomepizole ineffective. Local company in the deaths of 21 patients and the syrup were sent by to... Dibenzoate - Similar structures search, synonyms, diethylene translation, English dictionary definition of diethylene bis. Water and many diethylene glycol ( IUPAC name: ethane-1,2-diol ) is an organic compound the! Is more hazardous to humans than implied by oral toxicity data in laboratory animals. 3., being partially filtered in the kidneys for elimination, oxygen, hydrogen peroxide, perchloric and... Who survive but develop kidney failure parents revealed significant contamination with DEG O ;. 3-Hexyne ) buyers, Wang falsified his license and laboratory analysis reports doctors had no idea what was happening the... Were sent by jet to CDC for analysis taken a Medicine called “ My Pikin Baby ”, teething. The high mortality rate DEG intoxication produces CDC for analysis and plasticizers 14, 2007, 14249974 10864135. Are produced Cruz, legal representative of Medicom, remains in jail a...